The synthesis process of sildenafil.(Viagra)

 

Sildenafil, commonly known by its brand name Viagra, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. The synthesis of sildenafil involves several chemical reactions. However, it's important to note that the synthesis of sildenafil is a complex process that requires specialized knowledge and facilities. It should only be carried out by trained professionals in a controlled laboratory setting.

The following is a simplified overview of the synthesis process of sildenafil:

Preparation of starting materials:

3,4-dihydroxybenzaldehyde: 

This compound can be prepared by several methods, such as the condensation of 3,4-dihydroxybenzylamine with formaldehyde.

3,4-dihydroxybenzaldehyde

N-methyl-4-piperidone: 

This compound can be synthesized through the reaction of piperidine with methyl acrylate.

N-methyl-4-piperidone

Formation of the pyrazolopyrimidinone core:

The reaction begins by combining 3,4-dihydroxybenzaldehyde with N-methyl-4-piperidone to form a Mannich base.

The Mannich base is then reacted with ethyl acetoacetate and ammonium acetate to form a pyrazolopyrimidinone intermediate which is precursor of sildenafil.

pyrasolopyrimidinone.

Introduction of the pyrazolopyrimidinone core to form sildenafil:

The pyrazolopyrimidinone intermediate is reacted with chloroacetyl chloride and methyl piperazine to form a key intermediate known as a chlorosulfonyl compound.

The chlorosulfonyl compound is then reacted with sodium cyanide to form the cyano compound.

The cyano compound is hydrolyzed to yield the final product, sildenafil.

It's important to reiterate that this is a simplified summary, and the actual synthesis process of sildenafil involves additional steps, purification, and quality control measures.